ASH 2019: langetermijn follow-up van HD14 bij HL

Bastian von Tresckow presenteerde op ASH 2019 een lange termijn analyse van HD14, waarmee men een definitief antwoord probeerde te vinden voor de keuze tussen behandelen met 4x ABVD of met 2xABVD + 2x BEACOPP bij vroeg stadium unfavorable HL (abstract). Bekijk ook ons ASH-journaal over lymfomen, waarin prof. dr. Josée Zijlstra en dr. Elly Lugtenburg hun ASH-highlights m.b.t. lymfomen bespreken, waaronder de studie van dr. Von Tresckow. 

In early unfavorable Hodgkin Lymphoma (HL), long-term tumor control with 4xABVD and 30Gy involved field radiotherapy (IFRT) is approximately 80%. To improve these results, the GHSG HD14 trial compared an intensified chemotherapy regimen consisting of 2xBEACOPPescalated plus 2xABVD (2+2) to 4xABVD. All patients received 30Gy IFRT. Due to a progression-free survival (PFS) difference of 6.2% at five years in favor of the intensified treatment, 2+2 plus 30Gy RT is the current GHSG standard and is a treatment option in the NCCN guidelines for early unfavorable HL. However, there was no overall survival (OS) difference between 2+2 and 4xABVD at the final analysis of HD14 and the potential long-term toxicity of 2+2 is debated. We therefore performed a long-term follow up analysis of HD14.