The first program of these series presented to you from Cardiostim EHRA Europace 2014 provides an update on stroke prevention and anticoagulation. Prof. dr. Gerhard Hindricks (Leipzig, Germany) provides an update on the current approach when stopping anticoagulation in AF patients might be an option. Prof. dr. Hein J. Heidbüchel (Leuven, Belgium) explains the use of anticoagulation in AF according to the practical guide, which is presented as an addition to the European anticoagulation guidelines. Dr. Robert P. Giugliano (Boston, MA, USA) deals with the results of the ENGAGE AF- TIMI 48 trial. He presents five updated results of subgroup analysis.